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2013年10月29日

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【姓         名】吳彰哲 (Chang-Jer Wu, Ph. D.)

職      】教授 (Professor)

學   歷】國防醫學院博士 (National Defense Medical Center)

專   長】分子生物學、病毒學、免疫學、生物技術學 (Molecular Biology, Virology, Immunology, Biotechnology)

聯絡電話(02)2462-2192 # 5137

電子信箱cjwu@mail.ntou.edu.tw

教授課程】食品生物技術、生物化學、微生物學、應用微生物學、免疫學、生物工程概論、高等食品生物技術

【研究方向】

1.      新一代疫苗技術-基因疫苗的建立與開發

2.      機能性食品輔助新興傳染病預防及治療之研究

3.      抗病毒藥物篩選及機制之研究

4.      抗癌藥物篩選及機制之研究

【近年研究計畫】

年別

計劃名稱

單位

98

開發抗登革病毒與腸病毒71型的藥物及疫苗之快速篩選平台--抗登革病毒及腸病毒71型的藥物及疫苗之研發(總計畫及子計畫一)(1/3)

國科會

98

抗幽門螺旋桿菌(Helicobacter pylori)感染之DNA疫苗及口服疫苗之研發(1/3)

國科會

96

兒茶素(EGCG)抑制laminin受器媒介的癌細胞轉移及調節癌細胞GM-CSF訊息傳遞之研究

國科會

95

研發疫苗新佐劑配方加強日本腦炎DNA疫苗之免疫活性(II)

農委會

95

兒茶素(EGCG)抑制日本腦炎病毒感染之研究

國科會

95

日本腦炎DNA疫苗新的傳輸策略--皮膚滲透免疫法(2/2)

國科會

94

日本腦炎DNA疫苗新的傳輸策略--皮膚滲透免疫法(1/2)

國科會

94

日本腦炎DNA疫苗在豬隻之效能研發

國科會

93

研發疫苗新佐劑配方加強日本腦炎DNA疫苗之免疫活性(I)

國科會

93

高效能的日本腦炎DNA疫苗之研發(II)

農委會

92

利用日本腦炎DNA疫苗做為基因槍效能之研發

國科會

92

利用siRNA抑制嚴重急性呼吸道症候群(SARS)冠狀病毒複製研究

國科會

92

利用siRNA相關技術研發抑制日本腦炎病毒複製之新藥

國科會

91

高效能的日本腦炎DNA疫苗之研發(I)

國科會

91

利用CpG motif做為日本腦炎DNA疫苗佐劑之研發

國科會

著作目錄  

發表之論文:

年別

題目

2010

Chai, H. J., J. H. Li, H. N. Huang, T. L. Li, Y. L. Chan, C. Y. Shiau and C. J. Wu. Effects of sizes and conformations of fish scale collagen peptides (FSCPs) on facial skin qualities and transdermal penetration efficiency. Journal of Biomedicine and Biotechnology.

2010

吳彰哲,黃瀚寧. 蝦蟹殼中的寶貝-幾丁質. 科學發展月刊. 448, 12-19.

2010

Chuang, K. H., S. C. Tzou, T. C. Cheng, C. H. Kao, W. L. Tseng, J. Shiea, K. W. Liao, Y. M. Wang, Y. C. Chang, B. J. Huang, C. J. Wu, P. Y. Chu, S. R. Roffler and T. L. Cheng. Measurement of poly(ethylene glycol) by cell-based anti-poly(ethylene glycol) ELISA. Anal Chem., 82:2355-2362.

2010

Lin, C. S., P. J. He, N. M. Tsai, C. H. Li, S. C. Yang, W. T. Hsu, M. S. Wu, C. J. Wu, T. L. Cheng and K. W. Liao. A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis. Biochem Biophys Res Commun., 392:183-189.

2009

Chang, L. P., Y. S. Lai, C. J Wu and T. C. Chou. Liquid perfluorochemical inhibits inducible nitric oxide synthase expression and nitric oxide formation in lipopolysaccharide-treated RAW 264.7 macrophages. Journal of Pharmaceutical Sciences., 111:147-154.

2009

Huang, Y. T., S. Y. Lyu, P. H. Chuang, N. S. Hsu, Y. S. Li, H. C. Chan, C. J. Huang, Y. C. Liu, C. J. Wu, W. B. Yang and T. L. Li. In vitro Characterization of Enzymes Involved in the Synthesis of Nonproteinogenic Residue (2S, 3S)-beta-Methylphenylalanine in Glycopeptide Antibiotic Mannopeptimycin. Chembiochem., 10:2480-2487.

2009

Huang, H. N., T. L. Li, Y. L. Chan, C. L. Chen and C. J. Wu. Transdermal immunization with low-pressure-gene-gun mediated chitosan-based DNA vaccines against Japanese encephalitis virus. Biomaterials., 30:6017-6025.

2009

Yang, S. W., Y. S. Lee, T. A. Chen, C. J. Wu, and C. N. Tsai. Human papillomavirus in oral leukoplakia is no prognostic indicator of malignant transformation. Cancer Epidemiology., 33: 118-122.

2009

Cheng, J. Y., H. N. Huang, W. C. Tseng, T. L. Li, Y. L. Chan, K. C. Cheng and C. J. Wu. Transcutaneous immunization by lipoplex-patch based DNA vaccines is effective vaccination against Japanese encephalitis virus infection. Journal of Controlled Release., 135:242-249.

2007

Li, Y. S., J. Y. Ho, C. C. Huang, S. Y. Lyu, C. Y. Lee, Y. T. Huang, C. J. Wu, H. C. Chan, C. J. Huang, N. S. Hsu, M. D. Tsai and T. L. Li. A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation. Journal of the American Chemical Society., 129:13384-13385. (SCI)

2006

Ho, J. Y., Y. T. Huang, C. J. Wu, Y. S. Li, M. D. Tsai and T. L. Li, 2006, Glycopeptide biosynthesis: Dbv21/Orf2* from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase. Journal of the American Chemical Society., 128:13694-13695. (SCI)

2006

Wu, C. J., T. L. Li, H. W. Huang, M. H. Tao and Y. L. Chan, 2006, Development of an effective Japanese encephalitis virus-specific DNA vaccine. Microbes and Infection., 8:2578-2586. (SCI)

2006

Wu, C. J. and Y. L. Chan, 2006, Antiviral applications of RNAi for coronavirus. Expert Opin. Investig. Drugs., 15:89-97. (SCI)

2005

Chaung, H. C., Y. Z. Chen, W. B. Chung, C. J. Wu, 2005, Generation and characterization of dendritic cells derived from swine bone marrow haematopoietic cells in vitro. Taiwan Veterinary Journal., 31:195-207.

2005

Wu, C. J., H. W. Huang, C. Y. Liu, C. F. Hong and Y. L. Chan, 2005, Inhibition of SARS-CoV replication by siRNA. Antiviral Research., 65:45-48. (SCI)

2004

Wu, C. J., J. T. Jan, C. M. Chen, H. P. Hsieh, Y. S. Chao, H. W Liu, C. Y. Liu, H. W. Huang, S. C. Chen, C. F. Hong, R. K. Lin, D. R Hwang and J. T. A. Hsu, 2004, Inhibition of SARS-CoV replication by niclosamide, Antimicrobial Agents and Chemotherapy., 48:2693-2696. (SCI)

2004

Wu, C. J., S. C. Lee, H. W. Huang and M. H. Tao, 2004, In vivo electroporation of skeletal muscle increases the efficacy of Japanese encephalitis virus DNA vaccine, Vaccine., 22:1457-1464. (SCI)

2003

Chou, T. C., E. Fu, C. J. Wu, J. H. Yeh, 2003, Chitosan enhances platelet adhesion and aggregation, Biochem Biophy Res Comm., 302:480-483. (SCI)

2003

Hsieh Y. H., C. J. Wu, K. P. Chow, C. L. Tsai, and Y. S. Chang, 2003, Electroporation-mediated and EBV LMP1-regulated gene therapy in a syngenic mouse tumor model, Cancer Gene Ther., 10:626-636. (SCI)

2003

Lee, S. C., C. J. Wu, P. Y. Wu, Y. L. Huang, C. W. Wu and M. H. Tao, 2003, Inhibition of established subcutaneous and metastatic murine tumors by intramuscular electroporation of the interleukin 12 gene, J Biomed Sci., 10:73-86. (SCI)

2003

Wu, C. J., H. W. Huang and M. H. Tao, 2003, Induction of cross-protection against two wild-type Taiwanese isolates of Japanese encephalitis virus using Beijing-1 strain DNA vaccine, Vaccine., 21:3938-3945. (SCI)

2001

吳彰哲, 2001, 21世紀的癌症新療法-樹突狀細胞(Dendritic cell)免疫療法, 食品工業, 33, 8: 21-26.

2000

吳彰哲, 2000, 鼻咽癌(Nasopharyngeal Carcinoma): Epstein-Barr病毒致病機制和治療策略之簡介, 中化藥訊, 46, 12-19.

1998

Wu, C. J., C. Y. Leu, S. T. Liu, K. P. Chiu, C. L. Meng and Y. S. Chang, 1998, Transcriptional activation of NF-B activity by Epstein-Barr virus (EBV) LMP1 as a selective therapeutic strategy for EBV-associated diseases, Gene Therapy, 5:905-912. (SCI)

1997

Wu, C. J., K. S. S. Chang and Y. S. Chang, 1997, Transfer of the E6 and E7 genes of human papillomavirus type 18 into human epithelial cells via recombinant retrovirus infection, J Microbiol Immunol Infect., 30:123-134.

1997

Yeh, T. S., S. N. Li, C. J. Wu, S. T. Liu, C. L. Meng and Y. S. Chang, 1997, Sequence variations between two Epstein-Barr virus LMP1 variants have no effect on activation of NF-kB activity, DNA and Cell Biology., 16:1311-1319. (SCI)

 專書著作:

年別

題目

2007

吳彰哲, 2007. 細胞培養與食品. 潘崇良編着, 食品生物技術. 華格那企業有限公司.

2007

吳彰哲, 2007. 動物生物技術與食品. 潘崇良編着, 食品生物技術. 華格那企業有限公司.

2006

Wu, C. J. and Y. L. Chan., 2006. Coronaviruses and severe acute respiratory syndrome associated coronavirus (SARS-CoV). In: Hefferon, K.L. (Eds.), Recent advances in RNA virus replication, first ed. Transworld research network, Kerala, India, pp. 29-44.

2006

吳彰哲編譯. 2006. 細胞與分子生物學. 合記圖書出版社.

專利:

年別

題目

2008

吳彰哲, 陶秘華. 日本腦炎DNA疫苗. 中華民國發明專利, 發明第I302166. 2008.10.21-2026.1.1.

研討會發表之論文:

年別

題目

2009

Wu C. J., H. N. Huang, 2009, Transcutaneous immunization by chitosan complex-patch based DNA vaccines is effective vaccination against Japanese encephalitis virus infection, The 3nd Global Congress on Vaccine, Singapore.

2009

Tsai, L. W., C. J. Wu, 2009, The polysaccharide extracts from Ulva lactuca can inhibit the infection of enterovirus 71, The 24th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2009

Tu, Y., C. J. Wu, 2009, Epigalocatechin-3-gallate (EGCG) inhibit the growth and metastasis of tumor through the signal transduction of 67-kDa laminin receptor, The 24th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2008

Wu C. J., H. N. Huang, 2008, Japanese encephalitis virus DNA vaccine using the transcutaneous immunization by chitosan complexes, The 2nd Global Congress on Vaccine, Boston, USA.

2008

Huang, H. N., C. J. Wu, 2008, Japanese encephalitis virus dna vaccine using the transcutaneous immunization by chitosan complexes, The 23th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2008

Yang, S. F., C. J. Wu, 2008, Study of the effects on the inhibition of Japanese encephalitis virus infection in mice brain after (-)-epigallocatechin gallate (EGCG) treatment, The 23th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2008

Tung, H. M., C. J. Wu, 2008, Using three types of oral vaccines against Helicobacter pylori infection, The 23th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2007

Cheng, J. Y., H. N. Huang, K. C. Cheng, C. J. Wu, 2007, A new delivery strategy of japanese encephalitis virus dna vaccine using the transcutaneous immunization, The 22th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2007

Chu, Y. H., H. M. Tung, C. J. Wu, 2007, Using IgY to suppress the infection of Vibrio Alginolyticus in small abalone, The 22th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2007

Ciou, Y. H., C. J. Wu, 2007, Study of inhibitory effects of japanese encephalitis virus infection by the extracts of taiwan algae, The 22th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2007

Jhan, M. Y., S. F. Yang, S.Y. Liou, C. J. Wu, 2007, Study of inhibitory effects by catechins in japanese encephalitis virus infection, The 22th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2005

Ku, M. C., C. J. Wu, Y. N. Huang, S. F. Chi, J. Y. Wang, 2005, Vitamin D3 surpresses the production of proinflammatory cytokines and chemokines production from glial cells in Japanese encephalitis virus infected mice, The 20th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2005

Wu, C. J., H. W. Huang, C. Y. Liu, C. F. Hong, Y. L. Chan, 2005, Inhibition of SARS-coronavirus replication by siRNA, The 20th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2005

Wu, C. J., H. W. Huang, Y. L. Chan, 2005, Construct a clinical used and high efficient dna vaccine of Japanese encephalitis virus, The 20th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2005

Wu, Y. S., P. H. Lu, Y. C. Chao, J. T. Jan, C. J. Wu, C. M. Chen, J. P. Liou, H. R. Lo, S. H. Ma, Y. S. Chao, T. A. Hsu, H. P. Hsieh, 2005, Promazine Analogues as Potential Anti SARS-CoV Drugs. The 229th ACS National Meeting, San Diego, California.

2004

Chi, S. F., C. J. Wu, Y. N. Huang, J. Y. Wang, 2004, Japanese encephalitis virus infects neurons and microglia in brain and spinal cord in mice, The 19th Joint Annual Conferenceof Biomedical Sciences, Taiwan.

2003

Wu, C. J., M. F. Chang, M. H. Tao, H. W. Liu, S. R. Roffler, 2003, Aminopeptidase N/ CD13 is not the SARS coronavirus receptor, International conference on influenza and the resurgence of severe acute respiratory syndrome (SARS), Taiwan.

2003

Wu, C. J., Y. L. Chan, C. T. Yeh, S. C. Chen, Y. W. Hung and M. H. Tao, 2003, Construct a clinical used and high efficient DNA vaccine of Japanese encephalitis virus, The 15th European Immunology Congress (EFIS 2003), Rhodes, Greece.

2003

Wu, C. J., Y. L. Chan, H. W. Huang and M. H. Tao, 2003, In vivo electroporation of skeletal muscle increases immunogenicity of JEV DNA vaccine without cardiotoxin-pretreatment, The 15th European Immunology Congress (EFIS 2003), Rhodes, Greece.

2002

Wu, C. J., 2002, Development of a highly efficient DNA vaccine for Japanese encephalitis virus, The 29th National Defense Medical Conference, Taiwan.

2000

Wu, C. J., H. W. Huang and M. H. Tao, 2000, In vivo electroporation of skeletal muscle increases immunogenicity of DNA vaccine, Australasian Society of Immunology 30th Annual Conference, Australasian.

1999

Wu, C. J., K. S. S. Chang and Y. S. Chang, 1999, Transfer of the E6 and E7 genes of human papillomavirus type 18 into human epithelial cells via recombinant retrovirus infection, Symposium of the 30th Annual Conference of Microbiology and Immunology, Taiwan.

1998

Wu, C. J., C. Y. Leu, S. T. Liu, K. P. Chiu, C. L. Meng and Y. S. Chang, 1998, Transcriptional activation of NF-kB activity by Epstein-Barr virus (EBV) LMP1 as a selective therapeutic strategy for EBV-associated diseases, The 6th Symposium on Recent Advances in Cellular and Molecular Biology, Taiwan.

1996

Yeh, T. S., S. N. Li, C. J. Wu, S. T. Liu, C. L. Meng and Y. S. Chang, 1996, Sequence variations between two Epstein-Barr virus LMP1 variants have no effect on activation of NF-kB activity, The 7th Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, Hong Kong.

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